The action of ganglionic blocking drugs on the synaptic responses of rat submandibular ganglion cells

摘要

1 The effects of tubocurarine, hexamethonium and trimetaphan on the synaptic currents of rat submandibular ganglion cells have been measured at 20°C by means of a two-microelectrode voltage-clamp system. The aim was to distinguish between the receptor-blocking and channel-blocking actions of those drugs, and to test for possible selectivity of action on the `fast' and `slow' acetylcholine-operated channels.